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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Prog Retin Eye Res. 2020 Sep 4;82:100901. doi: 10.1016/j.preteyeres.2020.100901

Figure 5.

Figure 5.

Brimonindine tartrate-dendrimer nanofiber (BT/DNF) mats reduce intraocular pressure. In vivo 3-week daily dose response is shown. Brown Norway rats (n=4) received a daily dose of brimonidine via saline eye drops or DNF mat for three weeks. IOP was recorded immediately prior to drug application. Values expressed are the difference between the experimental and contralateral eyes after normalizing individual eyes to baseline levels. The dash lines represent the mean IOP reduction values. DNF mat delivery system was able to sustain IOP reduction over the test period compared to saline eye drops (# indicates significant difference, P < 0.001). Error bars represent standard deviation. Reprinted with permission from Lancina et al., 2017. Copyright 2017 American Chemical Society.