Table 3.
Prostaglandin eye drops and clinically advanced or late stage sustained release delivery systems. Dose ratio relative to intracameral route is included for bimatoprost, the most clinically successful prostaglandin for sustained delivery.
| Route | Product | Manufacturer | Strength/ Total dose/ Frequency | Daily dose (μg/Day) | Dose (μg/180 Days | Dose ratio relative to intracameral |
|---|---|---|---|---|---|---|
| Bimatoprost | ||||||
| Topical eye drop solution | Lumigan | Allergan | 0.1 mg/mL or 0.3 mg/mL, 1 drop q.d. (pm) | 5 μg/Day or 15 μg/Day | 900 or 2700 μg | 45 or 135 |
| Conjunctival fornix insert | Fornix ring insert | Allergan | 13 mg, 1 insert, delivers for 6 months | To - 35 μg/Day T180 - 6 μg/Day |
13,000 | 650 |
| Intracameral implant | Durysta | Allergan | 10 μg, 1 implant, delivers for 3 months | 0.1 μg/Day to 0.9 μg/Day | 20 | 1 |
| Latanoprost | ||||||
| Topical eye drop solution | Xalatan | Pfizer | 50 μg/mL | 2.5 μg/Day | ||
| Topical nondegradable insert | Eye-D VS101 | BioLight Life Sciences Ltd. | High, medium, and low doses, delivers for 3 months | N/A+ | ||
| Punctum or nasolacrimal duct plug | L-PPDS Punctal plug | Mati Therapeutics | Low dose: 70.5 μg (1 plug) High dose:141 μg (2 plugs), delivers for 4 weeks |
3.0 μg/Day* | ||
| EXP-LP Punctal plug | Eximore, Ltd. | Low dose: 250 μg High dose: 450 μg |
1.38 μg/Day 2.50 μg/Day |
|||
| Intracameral implant | PA5108 For latanoprost free acid | PolyActiva | Study 1 doses - 8.9, 14.7, 26.6, and 35.5 μg. Study 2 doses – 16.2, 30, 45, and 60 μg, delivers for 3 months |
N/A+ | ||
| Travoprost | ||||||
| Topical eye drop solution | Travatan Z | Novartis | 40 μg/mL | 2 μg/Day | ||
| Punctum or nasolacrimal duct plug | OTX-TP2 | Ocular Therapeutix | N/A, delivers for 2 or 3 months | N/A+ | ||
| Sclera-anchored implant | iDose | Glaukos Corp. | Two doses, delivers for 6–12 months | N/A+ | ||
| Intracameral implant | Travoprost XR-ENV515 OTX-TIC | Envisia Therapeutics Ocular Therapeutix |
42.5 μg, delivers for 6–12 months N/A, delivers for 3 months |
N/A+ N/A+ |
||
*
Punctal plugs were designed to release drug at this rate
+
Not available