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. Author manuscript; available in PMC: 2021 Oct 22.
Published in final edited form as: J Med Chem. 2020 Oct 15;63(20):11522–11547. doi: 10.1021/acs.jmedchem.0c00531

Figure 2.

Figure 2.

Single concentration (50 μM; n = 4 per compound) screening of the parental PLEV tetrapeptide and its analogs against the PPI between FGF14 and the CTD of Nav1.6 using the LCA. Transfected cells were incubated with compounds for 1 hour prior to luminescence reading, and maximal luminescence for each well was normalized to per plate 0.5% DMSO controls (n = 32 per plate). Individual replicate values with mean ± SEM over at least three independent experiments are shown. A one-way ANOVA with post hoc Dunnett’s multiple comparisons test was used to determine statistical significance. F (29, 324) = 137.3; *, p<0.0005.