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. Author manuscript; available in PMC: 2021 Oct 22.
Published in final edited form as: J Med Chem. 2020 Oct 15;63(20):11522–11547. doi: 10.1021/acs.jmedchem.0c00531

Figure 3.

Figure 3.

Determination of the potency (IC50) of twelve compound 2 analogs. Utilizing the LCA, peptidomimetics were tested at eight concentrations (range: 0.25 – 100 μM; n = 4 replicates per concentration). Data are shown as mean percent luminescence (relative to on-plate 0.5% DMSO controls) values ± SEM. GraphPad Prism 8 software was used for non-linear curve fitting to estimate the half maximal inhibitory concentration for compound 2 analogs, and their corresponding IC50 and efficacy values are shown in Table 4.