Table 4.
IC50 Values and Efficacy of Top Peptidomimetics.a
| Compound | IC50 (μM) | Efficacy (%) |
|---|---|---|
| 13c | 49.0 ± 11.3 | 82.1 |
| 17 | 22.4 ± 1.1 | 93.3 |
| 19k | 15.4 ± 0.3 | 90.7 |
| 19e | 33.4 ± 2.4 | 96.9 |
| 21a | 20.4 ± 0.6 | 96.1 |
| 23a | 11.5 ± 0.6 | 95.5 |
| 23b | 13.8 ± 1.4 | 96.6 |
| 23c | 25.1 ± 9.6 | 91.4 |
| 23d | 33.9 ± 6.4 | 92.1 |
| 23e | 35.3 ± 4.4 | 69.9 |
| 23f | 13.3 ± 0.6 | 82.3 |
| 23g | 22.5 ± 6.1 | 83.3 |
a
Potency (estimated IC50, value ± SEM; μM) and efficacy (percent inhibition, calculated as the inverse of normalized luminescence at the bottom plateau) values for twelve compound 2 analogs were determined using the dose response curves shown in Figure 3.