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. Author manuscript; available in PMC: 2021 Oct 22.
Published in final edited form as: J Med Chem. 2020 Oct 15;63(20):11522–11547. doi: 10.1021/acs.jmedchem.0c00531

Table 5.

Determination of Protein:ligand Binding of Compound 2 Analogs to FGF14 and Nav1.6 by Thermal Shift.

ΔTM (°C)*
Compound FGF14 Nav1.6
19k 0.67 ± 0.05 −0.87 ± 0.48
19e 3.38 ± 0.08 −0.48 ± 0.79
21a −2.27 ± 0.18 −4.64 ± 0.43
23a −4.55 ± 0.13 0.04 ± 0.07
23b −1.85 ± 0.40 −0.15 ± 0.12
23d −0.89 ± 0.15 −0.13 ± 0.20
23e −2.21 ± 0.39 0.43 ± 0.47
*

Change in melting temperature (°C) was calculated relative to per plate FGF14 and Nav1.6 protein alone controls.