. Author manuscript; available in PMC: 2021 Oct 22.

Published in final edited form as: J Med Chem. 2020 Oct 15;63(20):11522–11547. doi: 10.1021/acs.jmedchem.0c00531

Table 8.

Functional modulation of Na_v1.6 in the absence of FGF14 by 10 μM 21a compared to 0.1% DMSO.^a

Condition	Peak Current Density (pA/pF)	Tau of Fast Inactivation (ms)	V_1/2 of Activation (mV)	V_1/2 of Steady-State Inactivation (mV)	Long Term Inactivation (Depolarization Cycles 2–4)
Condition	Peak Current Density (pA/pF)	Tau of Fast Inactivation (ms)	V_1/2 of Activation (mV)	V_1/2 of Steady-State Inactivation (mV)	2	3	4
DMSO	−50.1 ± 3.1 (9)	1.22 ± 0.07 (9)	−25.4 ± 1.0 (7)	−62.0 ± 1.3 (5)	0.84 ± 0.03	0.76 ± 0.05	0.75±0.05 (6)
21a	−25.8 ± 2.3^*** (10)	1.45 ± 0.15 (10)	−16.9 ± 0.67^***(10)	−55.2 ± 0.85 (8)^**	0.87 ± 0.02	0.76 ± 0.03	0.70 ± 0.03 (6)

Summary of the electrophysiological evaluation of 21a against Na_v1.6 in the absence of FGF14. Results are expressed as the mean ± SEM. The number of independent experiments is shown in parentheses. A Student’s t-test was used to determine statistical significance.

^**,

p < 0.005;

^***,

p < 0.0005.