Table 3.

Plasma BNZ-1 Pharmacokinetic Parameters Following a Single Intravenous Infusion

Pharmacokinetic Parameters	BNZ-1 Dose Group
	0.2 mg/kg (n = 3)	0.4 mg/kg (n = 3)	0.8 mg/kg (n = 3)	1.6 mg/kg (n = 3)	3.2 mg/kg (n = 3)	6.4 mg/kg (n = 3)
AUC0-t (μg • h/mL)	934 (35.7)	1780 (42.0)	4140 (22.4)	1170 (13.1)	19 600 (2.9)	45 900 (21.6)
AUC0-inf (μg • h/mL)	1280 (31.0)	2260 (29.4)	4450 (19.1)	12 200 (14.1)	20 100 (2.4)	46 700 (21.4)
AUC%extrap	26.3 ± 12.0	21.1 ± 9.38	6.90 ± 3.32	3.87 ± 1.47	2.44 ± 0.613	1.62 ± 0.870
Cmax (μg/mL)	9.91 (22.9)	17.6 (6.5)	31.4 (30.9)	101 (4.3)	153 (17.8)	386 (43.0)
tmax (h)	0.115 (0.100, 0.140)	0.105 (0.104, 1.02)	2.02 (2.02, 2.06)	2.02 (1.88, 2.08)	0.173 (0.165, 2.11)	0.173 (0.166, 2.08)
Kel (1/h)	0.00658 ± 0.000960	0.00663 ± 0.00196	0.00599 ± 0.000542	0.00622 ± 0.000990	0.00557 ± 0.00148	0.00539 ± 0.000780
t1/2 (h)	107 ± 15.5	112 ± 39.0	116 ± 10.9	113 ± 16.9	130 ± 31.7	130 ± 17.4
CL (mL/h)	11.9 ± 2.92	13.3 ± 3.78	13.4 ± 1.86	12.3 ± 3.65	10.8 ± 2.47	13.5 ± 2.86
Vd (mL)	1760 ± 309	1950 ± 290	2020 ± 179	1710 ± 474	1660 ± 135	2020 ± 95.5

AUC_0-inf, area under the plasma concentration–time curve from time 0 to time of last measurable concentration; AUC_0-t, area under the plasma concentration–time curve from time 0 to time of last measurable concentration; AUC%extrap, percentages of area under curve extrapolated to infinity; CL, clearance; C_max, maximum observed plasma concentration; K_el, apparent terminal elimination rate constant; t_1/2, terminal elimination half-life; t_max, time to maximum observed plasma concentration; Vd, volume of distribution.

AUCs and C_max values are presented as geometric mean and geometric coefficient of variation.

T_max values are presented as median (minimum, maximum). AUC%extrap, K_el, t_1/2, CL, and V_d are presented as mean ± standard deviation.