Fig 6.

Female nude mice were inoculated subcutaneously with SW48 cells in the right flank and underwent treatment beginning at 7 days post inoculation (plotted as day 0). Each data point represents average tumor volume for n=8 animals treated with LMB-100, Oxaliplatin, combination Oxaliplatin and LMB-100, or PBS control. There is a significant difference between groups treated with RIT monotherapy or combination RIT-Oxaliplatin therapy (p<0.05) beginning on day 12 (indicated by *) and persisting throughout the experiment. There is no significant difference noted between combination therapy or combination RIT therapy.