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Mechanisms of cholinergic anti-inflammatory pathway. The CAIP depends on norepinephrine produced by splenic sympathetic fibers, which can lead ChAT+T cell to release ACh through β2 receptor. ACh from ChAT+T cell binds to the α7-nAChR on the bone marrow-derived non-T cells like macrophages along with inhibiting LPS-mediated cytokine production.
