Table 1.
Demographic characteristics and compliance in the FAS population.
| Parameter | Rabeprazole | Anaprazole | P-value | |
|---|---|---|---|---|
| 10 mg (n = 50) | 20 mg (n = 47) | 40 mg (n = 48) | ||
| Demographic and clinical characteristics | ||||
| Age (mean ± SD, y) | 45.1 ± 10.75 | 39.5 ± 12.72 | 41.0 ± 11.97 | 0.0549 |
| Males [No. (%)] | 37 (74.0) | 33 (70.2) | 32 (66.7) | 0.7299 |
| Height (mean ± SD, cm) | 167.83 ± 7.888 | 166.47 ± 8.418 | 167.06 ± 8.156 | 0.7117 |
| Weight(mean ± SD, kg) | 65.70 ± 12.251 | 62.64 ± 10.518 | 63.34 ± 9.540 | 0.3455 |
| BMI (mean ± SD, kg/m2) | 23.17 ± 3.456 | 22.49 ± 3.031 | 22.60 ± 2.562 | 0.4934 |
| PU history [No. (%)] | 25 (50.0) | 21 (44.7) | 22 (45.8) | 0.8575 |
| Other digestive disease [No. (%)] | 41 (82.0) | 37 (78.7) | 37 (77.1) | 0.8294 |
| PU-related drug use history over 4 weeks [No. (%)] | 7 (14.0) | 5 (10.6) | 11 (22.9) | 0.2481 |
| PU-related surgery history [No. (%)] | 0 | 1 (2.1) | 1 (2.1) | 0.9982 |
| H. pylori status, positive [No. (%)] | 40 (80.0) | 37 (78.7) | 38 (79.2) | 0.9876 |
| Endoscopic findings | ||||
| Number of ulcers | ||||
| 1 | 36 (72.0) | 38 (80.9) | 39 (81.3) | 0.4613 |
| 2 | 14 (28.0) | 9 (19.1) | 9 (18.8) | 0.4613 |
| Location of ulcers: duodenal bulb | 49 (98.0) | 47 (100.0) | 48 (100.0) | 0.9959 |
| Size of ulcer 1 (mean ± SD) (mm) | 7.4 ± 3.08 | 6.5 ± 2.76 | 6.4 ± 2.31 | 0.1214 |
| Stage of ulcer 1 [No. (%)] | ||||
| A1 | 35 (70.0) | 37 (78.7) | 38 (79.2) | 0.4910 |
| A2 | 15 (30.0) | 10 (21.3) | 10 (20.8) | 0.4910 |
| Size of ulcer 2 (mean ± SD) (mm) | 6.6 ± 3.33 | 6.2 ± 3.19 | 7.3 ± 2.29 | 0.7331 |
| Stage of ulcer 2 [No. (%)] | ||||
| A1 | 9 (64.3) | 7 (77.8) | 7 (77.8) | 0.7050 |
| A2 | 4 (28.6) | 2 (22.2) | 2 (22.2) | 0.9191 |
| H1 | 1 (7.1) | 0 | 0 | 0.9967 |
| Drug compliance | ||||
| Compliance within the acceptable range of 80–120% [No. (%)] | 50 (100%) | 47 (100%) | 47 (97.9%) | 0.9958 |
| Actual medication in total (mean ± SD, tablet/capsule) | 27.2 ± 4.03 | 27.4 ± 3.95 | 26.6 ± 5.20 | 0.4930 |
| Drug exposure time (mean ± SD, day) | 27.3 ± 4.03 | 27.4 ± 3.95 | 27.1 ± 4.93 | 0.7590 |
| Treatment frequency (mean ± SD, tablet/capsule per day) | 0.994 ± 0.023 | 0.999 ± 0.011 | 0.984 ± 0.068 | 0.3684 |
FAS, full analysis set; PU, peptic ulcer.