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. 2021 Jul 14;11:688461. doi: 10.3389/fonc.2021.688461

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Copyright © 2021 Xu, Kong, Fang, Fan, Yin, Sullivan, Tran, Clark, Sun, Hao, Zhao, Zhou and Bae-Jump

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ASP inhibited tumor growth in a transgenic mouse model of OC (KpB). The KpB mice were treated with 200mg/kg or 800mg/kg ASP daily for 4 weeks after ovarian tumors reached 0.1 cm in diameter. Treatment with 200 mg/kg ASP inhibited tumor growth in KpB mice (A). There was no significant difference in tumor weights after treatment with 200mg/kg versus 800mg/kg ASP (B). The KpB mice were then fed either a HFD (obese) or LFD (lean) at 3 weeks age of birth. The HFD and LFD mice were treated with 200 mg/kg ASP daily for 4 weeks when their ovarian tumors reached 0.1 cm in diameter. ASP significantly reduced tumor weights in both the HFD and LFD groups as compared to the vehicle treated controls (C). IHC results showed that ASP decreased Ki-67 expression in the ovarian tumor tissues in the obese and lean mice (D). *p < 0.05; **p < 0.01.