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ASP increased sensitivity to paclitaxel in OC cells. The OVCAR5 and SKOV3 ovarian cell lines were treated with 0.1 mg/ml ASP combined with different concentrations of paclitaxel for 48 hours. Cell proliferation was assessed by MTT assay. ASP combined with paclitaxel (0.1-5 nM) caused a synergistic cytotoxic effect in both cells (A, B). The combination index (CI) was calculated using CompuSyn software (C). *CI < 1: synergism, CI = 1: additive effect, and CI > 1: antagonism.
