Table 2.

Correlation analysis between HAVCR2/CTLA4 and gene biomarkers of immune cells in KIRC.

Immune cells	Biomarkers	HAVCR2		CTLA4
		Cor	P-value	Cor	P-value
CD8+ T cell	CD8A	0.367	***	0.674	***
	CD8B	0.359	***	0.621	***
T cell (general)	CD3D	0.311	***	0.726	***
	CD3E	0.333	***	0.742	***
	CD2	0.342	***	0.746	***
B cell	CD19	0.094	*	0.483	***
	CD79A	0.165	***	0.478	***
Monocyte	CD86	0.356	***	0.611	***
	CD115(CSF1R)	0.292	***	0.445	***
TAM	CCL2	0.075	0.0841	0.176	***
	CD68	0.314	***	0.286	***
	IL10	0.319	***	0.455	***
M1 Macrophage	INOS (NOS2)	0.09	*	-0.054	0.215
	IRF5	0.325	***	0.442	***
	COX2(PTGS2)	-0.1	*	0.075	0.0831
M2 Macrophage	CD163	0.315	***	0.307	***
	VSIG4	0.243	***	0.307	***
	MS4A4A	0.3	***	0.368	***
Neutrophils	CD66b (CEACAM8)	0.053	0.22	0.057	0.189
	CD11b (ITGAM)	0.312	***	0.397	***
	CCR7	0.244	***	0.558	***
Natural killer cell	KIR2DL1	0.033	0.441	0.057	0.188
	KIR2DL3	0.069	0.111	0.138	**
	KIR2DL4	0.076	0.0809	0.421	***
	KIR3DL1	0.058	0.18	0.056	0.199
	KIR3DL2	0.099	0.0224	0.187	***
	KIR3DL3	0.007	0.864	0.11	*
	KIR2DS4	-0.047	0.279	0.073	0.0937
Dendritic cell	HLA-DPB1	0.422	***	0.591	***
	HLA-DQB1	0.251	***	0.44	***
	HLA-DRA	0.445	***	0.582	***
	HLA-DPA1	0.439	***	0.569	***
	BDCA-1(CD1C)	0.214	***	0.285	***
	BDCA-4(NRP1)	0.107	*	-0.098	*
	CD11c (ITGAX)	0.299	***	0.582	***
Th1	T-bet (TBX21)	0.189	***	0.423	***
	STAT4	0.17	***	0.664	***
	STAT1	0.368	***	0.585	***
	IFN-g (IFNG)	0.291	***	0.672	***
	TNF-a (TNF)	0.12	**	0.314	***
Th2	GATA3	-0.053	0.224	0.318	***
	STAT6	0.161	***	0.096	*
	STAT5A	0.323	***	0.511	***
	IL13	-0.033	0.448	0.261	***
Tfh	BCL6	-0.112	**	0.228	***
	IL21	0.11	*	0.247	***
Th17	STAT3	0.212	***	0.123	**
	IL17A	-0.009	0.836	0.125	**
Treg	FOXP3	0.149	***	0.705	***
	CCR8	0.26	***	0.685	***
	STAT5B	0.204	***	0.007	0.875
	TGFb (TGFB1)	0.098	*	0.133	**
T cell exhaustion	PD-1 (PDCD1)	0.309	***	0.75	***
	CTLA4	0.205	***	1	***
	LAG3	0.294	***	0.707	***
	TIM-3 (HAVCR2)	1	***	0.205	***
	GZMB	0.124	**	0.445	***

*p < 0.05, **p < 0.01, ***p < 0.001.