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. 2021 Jul 14;14:657064. doi: 10.3389/fnmol.2021.657064

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Copyright © 2021 Lee, Mansuri, Wilson, Lam, Nairn and Picciotto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KEGG pathway analysis of significantly altered proteins in each pairwise comparison by sex and treatment group. Bar graphs show the five most significantly enriched KEGG pathways in the significantly up- and down-regulated proteins of each pairwise comparison as indicated in the (A) VTA after sub-chronic nicotine administration, (B) NAc shell after sub-chronic nicotine administration, and (C) VTA after chronic nicotine administration and withdrawal. Where less than five KEGG pathways are shown, only that number of pathways was identified as significantly enriched.