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. 2021 Jul 14;14:657064. doi: 10.3389/fnmol.2021.657064

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Copyright © 2021 Lee, Mansuri, Wilson, Lam, Nairn and Picciotto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PPI network analysis of differentially expressed proteins with and without chronic nicotine and withdrawal. PPI networks were constructed as described for Figure 6. (A) The top three clusters are shown for MC vs. FC in the VTA of C57BL/6J mice used for chronic nicotine administration. (B) Two clusters were identified for FN vs. FC in the VTA after chronic nicotine administration and withdrawal.