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. Author manuscript; available in PMC: 2021 Jul 28.
Published in final edited form as: J Med Chem. 2016 Jan 13;59(2):578–591. doi: 10.1021/acs.jmedchem.5b01153

Figure 3.

Figure 3.

Effects of compound (+)-22a on d-amphetamine (AMPH)-stimulated hyperlocomotion in the open field. (A) Locomotor activity in the open field in 5-min blocks reflecting baseline responses (0–15 min) and AMPH stimulated activity with its reduction by (+)-22a (15–120 min). (B) Cumulative baseline locomotor activities (0–15 min). (C) Cumulative AMPH-stimulated activities and reductions in activity with (+)-22a (16–90 min). N = 7–10 mice/treatment; *, p < 0.05, compared to the Veh + Veh group; #, p < 0.05, compared to the Veh + AMPH group.