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. Author manuscript; available in PMC: 2021 Jul 28.
Published in final edited form as: J Med Chem. 2016 Jan 13;59(2):578–591. doi: 10.1021/acs.jmedchem.5b01153

Table 2.

Liver Microsomal Stability of Compound (+)-22a.a

Assay Format Remaining Percentage (%)
HLM MLM
0 min 30 min 120 min 0 min 30 min 120 min
+ NADPH 100.0 91.9 70.5 100.0 68.1 32.4
− NADPH 100.0 94.7 81.9 100.0 97.8 79.6
a

Concentration of liver microsomes was 0.5 mg/mL and (+)-22a was tested at a concentration of 2 μM; HLM = human liver microsomes; MLM = mouse liver microsomes.