. Author manuscript; available in PMC: 2021 Jul 28.

Published in final edited form as: J Med Chem. 2016 Jan 13;59(2):578–591. doi: 10.1021/acs.jmedchem.5b01153

Table 3.

Brain Penetration Study of Compound (+)-22a.

Route	Time (h)	Animal ID	Brain (ng/g)	Plasma (ng/mL)	Ratio (Brain Plasma/)^a	Mean
ip 10 mg/kg	0.5	1	10120	321	31.5	29.9
	0.5	2	8480	300	28.3	29.9
	2.0	1	3948	96.4	41.0	45.0
	2.0	2	2228	45.4	49.1	45.0

Density of brain tissue is calculated as 1.0 g/mL.