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Cytochrome P450 Inhibition by Compound (+)-22a.a
| CYP Isoform (Substrate) | Inhibition (%) ± SEM |
|---|---|
| 1A2 (Phenacetin) | 86.0 ± 0.25 |
| 2C9 (Tolbutamide) | 29.2 ± 2.2 |
| 2C19 (Mephenytoin) | 32.0 ± 5.3 |
| 2D6 (Dextromethorphan) | 43.5 ± 3.0 |
| 3A4 (Midazolam) | 3.4 ± 1.6 |
Compound (+)-20a was tested at 10 μM; concentration of human liver microsomes was 0.2 mg/mL; concentration of phenacetin, tolbutamide, mephenytoin, dextromethorphan, and midazolam was 40, 200, 50, 10, and 5 μM respectively.
