Table 1.
Key characteristics of patients in each cohort.
| Cohort-0 | Cohort-1A | Cohort-1B | Cohort-2 | Cohort-3 | Cohort-4 | |
|---|---|---|---|---|---|---|
| N | 1057 | 632 | 250 | 130 | 137 | 289 |
| Man/Woman (woman %) | 223/834 (78.9%) | 296/336 (53.2%) | 104/146 (58.4%) | 60/70 (53.8%) | 50/87 (63.5%) | 81/208 (72.0%) |
| Age (years) | 30 (25, 36) | 28 (21, 34) | 31 (24, 36) | 30 (23, 36) | 29 (23, 35) | 30 (25, 36) |
| BMI (kg/m2) | 21.2 (19.9, 22.5) | 33.6 (30.2, 37.5) | 39.3 (35.7, 43.8) | 38.7 (34.6, 43.1) | 38.0 (34.5, 42.5) | 36.8 (31.9, 42.5) |
| Systolic pressure (mmHg) | 112 (106, 121) | 133 (122, 145) | 134 (125, 149) | 137 (128, 150) | 128 (124, 138) | NA |
| Diastolic pressure (mmHg) | 70 (64, 77) | 86 (78, 93) | 81 (74, 90) | 88 (79, 98) | 83 (75, 96) | NA |
| HbA1c (%) | 5.3 (5.0, 6.0) | 5.7 (5.4, 6.3) | 6.0 (5.6, 6.8) | 5.8 (5.4, 6.4) | 5.7 (5.4, 6.3) | 5.8 (5.4, 6.3) |
| Fasting glucose (mmol/l) | 4.6 (4.3, 5.0) | 5.2 (4.8, 5.8) | 5.5 (5.0, 6.8) | 5.1 (4.7, 6.0) | 5.4 (4.9, 6.4) | 5.4 (5.0, 6.2) |
| OGTT 2hr glucose (mmol/l) | 6.2 (5.1, 7.6) | 7.4 (6.1, 9.4) | 8.9 (6.7, 12.3) | 8.0 (6.6, 10.1) | 7.2 (5.9, 10.0) | NA |
| Fasting insulin (mU/l) | 9.13 (5.68, 13.57) | 25.45 (17.08, 35.48) | 28.19 (19.42, 42.63) | 26.66 (19.22, 38.49) | 33.09 (20.85, 49.21) | 27.87 (18.74, 42.24) |
| OGTT 2hr insulin (mU/l) | 64.30 (39.98, 101.90) | 125.95 (71.02, 217.00) | 137.10 (66.10, 233.90) | 139.30 (80.61, 221.50) | 112.10 (68.28, 192.20) | NA |
| Total cholesterol (mmol/l) | 4.22 (3.76, 4.67) | 4.78 (4.14, 5.44) | 4.53 (3.92, 5.19) | 4.52 (3.96, 5.27) | 5.08 (4.31, 5.59) | NA |
| Triglyceride (mmol/l) | 0.74 (0.60, 1.01) | 1.61 (1.15, 2.25) | 1.53 (1.17, 2.15) | 1.71 (1.15, 2.17) | 1.76 (1.29, 2.57) | NA |
| Uric acid (μmol/l) | 267 (236, 303) | 412 (341, 481) | 412 (359, 481) | 464 (373, 533) | 439 (377, 518) | 391 (318, 454) |
| Creatinine (μmol/L) | 56.0 (50.0, 62.0) | 68.1 (57.0, 77.8) | 59.4 (53.4, 68.7) | 55.5 (47.0, 66.0) | 60.9 (49.0, 68.3) | NA |
| ALT (U/L) | 13 (10, 16) | 43 (24, 75) | 42 (25, 77) | 46 (28, 80) | 47 (24, 81) | NA |
| AST (U/L) | 18 (15, 22) | 28 (20, 43) | 27 (18, 43) | 30 (20, 46) | 29 (20, 53) | NA |
Values are shown as median (IQR 25-75%). ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; HbA1c, glycosylated hemoglobin a1c; NA, not available; OGTT, oral glucose tolerance test.