Table 5.
The adjusted odds ratio (AOR) of comorbidities across the four clusters generated from Cohort-1 using k-means.
| MHO | HMO-U | HMO-I | LMO | |
|---|---|---|---|---|
| Hypertension | 1.00 | 1.97 (1.44-2.69) ## | 1.44 (0.86-2.41) | 1.85 (1.22-2.80) ## |
| Diabetes | 1.00 | 1.34 (0.96-1.87) | 0.98 (0.54-1.79) | 105.85 (42.00-266.74) ## |
| Dyslipidemia | 1.00 | 2.08 (1.51-2.87) ## | 2.32 (1.31-4.11) ## | 3.88 (2.29-6.57) ## |
| Hypercholesterolemia | 1.00 | 1.61 (1.16-2.22) ## | 1.63 (0.96-2.77) # | 1.70 (1.14-2.55) # |
| Hypertriglyceridemia | 1.00 | 1.79 (1.33-2.43) ## | 1.73 (1.05-2.84) # | 2.92 (1.96-4.36) ## |
| Low-HDL | 1.00 | 1.60 (1.17-2.19) ## | 2.26 (1.37-3.72) ## | 2.16 (1.45-3.20) ## |
| High-LDL | 1.00 | 1.88 (1.35-2.61) ## | 1.91 (1.13-3.24) # | 1.55 (1.02-2.35) # |
| Metabolic syndrome | 1.00 | 2.86 (2.09-3.92) ## | 1.89 (1.14-3.14) # | 13.50 (7.34-24.83) ## |
| Hyperuricemia | 1.00 | 73.67 (35.46-153.06) ## | 5.48 (3.08-9.77) ## | 1.70 (1.15-2.50) ## |
| Women hyper-testosterone | 1.00 | 3.38 (2.15-5.32) ## | 2.85 (1.17-6.93) # | 2.29 (1.22-4.31) # |
| PCOS | 1.00 | 2.07 (1.08-3.95) # | 14.44 (1.75-118.99) # | 1.53 (0.57-4.14) |
| Men hypo-testosterone | 1.00 | 2.06 (1.29-3.28) ## | 2.99 (1.53-5.82) ## | 2.19 (1.20-3.97) # |
| Microalbuminuria | 1.00 | 2.68 (1.2-5.95) # | 0.47 (0.09-2.39) | 3.35 (1.41-7.98) ## |
| NAFLD | 1.00 | 1.30 (0.48-3.49) | 1.15 (0.22-5.96) | 3.53 (0.43-29.17) |
| NAFLD with elevated ALT, AST | 1.00 | 1.97 (1.15-3.38) # | 1.47 (0.66-3.30) | 1.98 (1.01-3.85) # |
Values are shown as AOR (95%CI). Analyses are adjusted for sex and age. ALT, alanine aminotransferase; AST, aspartate aminotransferase; HDL, high density lipoprotein cholesterol; HMO-I, hypermetabolic obesity hyperinsulinemia subtype; HMO-U, hypermetabolic obesity hyperuricemia subtype; LDL, low density lipoprotein cholesterol; LMO, hypometabolic obesity; MHO, metabolic healthy obesity; NAFLD, nonalcoholic fatty liver disease; PCOS, polycystic ovary syndrome. MHO is the reference category. #P < 0.05, ##P < 0.01 vs. MHO.