Figure 2.

Respiration in high- vs. lower-altitude Tibetan groups. (A) Oxidative phosphorylation (OXPHOS) through mitochondrial complex I, complex I+II, non-phosphorylating (LEAK) respiration, and electron transfer system (ETS) maximum capacity respiration were statistically significantly increased in high-altitude Tibetan group compared to lower-altitude Tibetan group. Non-ETS respiration (ROX) and OXPHOS through mitochondrial complex IV did not change with altitude. (B) The respiratory control ration (RCR) was statistically significantly increased in the high-altitude Tibetan group compared to the lower-altitude Tibetan group. But the LEAK/ETS was not significant change. ns: p ≥ 0.05; ^**p < 0.01; ^****p < 0.0001. Statistical significance was determined via Student's t-test. Columns represent means and error bars present standard errors of the mean.