TABLE 1.

Sensitization associated with METH.

Conditions of cross sensitization/Resistance	Performance	References
Prenatal nicotine exposure increases sensitivity to METH	Motor behavior and conditioned hyperactivity was enhanced, and BDNF in the marginal cortex was changed	Lacy et al. (2016)
Intravenous METH injection increased the motivation to self-inject METH	Rats self-injected with more METH	Lacy et al. (2014)
The stresses of early mother-infant separation lead to vulnerability to METH intake	Metabolic syndrome was prolonged, METH intake was increased,and MeCP2 immunoreactivity in NAc region was decreased	Lewis et al. (2013)
Prenatal lead exposure enhances METH sensitization in rats	Behavioral sensitization occurs faster	Clifford et al. (2009)
Prenatal exposure to morphine, buprenorphine and methadone enhanced METH-induced behavioral sensitization	Motor activity and CPP activity were significantly increased, and the expression of dopamine D1R was lower in the NAc, and cAMP was dose-dependent	Chiang et al. (2014)
Prenatal METH exposure induces tolerance to cocaine	Shorter time in CPP testing of drug chambers	Alamberová et al. (2012)
Catecholamine-resistant cardiogenic shock occurred after prenatal METH exposure to the fetus	Dopamine, epinephrine, and norepinephrine dose increases were unresponsive and remained sluggish by day 4, and catecholamines responded well by day 9	Stanwood and Levitt, (2003)
Prenatal and neonatal exposure to bisphenol a enhances METH-induced sensitization	BPA treatment significantly enhanced METH-induced hyperactivity and sensitization, and the function of dopamine D1 receptor was upregulated, and the G-protein in the limbic forebrain was activated, and the level of dopamine D1 receptor gene was significantly increased	Suzuki et al. (2003)
Prenatal exposure to modafinil leads to an increased susceptibility to METH sensitization	The total distance of motion increased significantly in open-field test	Ruda Kucerova et al. (2018)
Prenatal methadone treatment increases METH sensitization	Prenatal methadone exposure not only promoted the development of METH-induced motor behavioral sensitization, but also restored behavioral sensitization in adolescent rats	Wong et al. (2014)