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. 2021 Jul 14;12:684538. doi: 10.3389/fphar.2021.684538

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Copyright © 2021 Cui, Chu, Yin, Chen, Wan, Luo, Dong and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Luminal CCh induced Ca²⁺-dependent duodenal I _sc via TRPV4-constituted SOCE. (A,B) luminal CCh(100 μM)-evoked I _sc after GdCl₃ (30 μM, n = 6) added to the serosal (s) side. (C,D) luminal CCh (100 μM) -evoked I _sc in wild-type (W.T.) or TRPV4 K.O. mice (n = 6). (E) luminal-stimulated I _sc after GdCl (Gd³⁺, 30 μM, n = 6) was added to the serosal (s) side of TRPV4 KO mice duodenum. Ctrl represents the control without drug treatment. Results are presented as mean ± SE. NS, no significant differences, *p < 0.05 vs. corresponding control by Student’s unpaired, two-tailed t-test.