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. 2021 Jul 14;12:684538. doi: 10.3389/fphar.2021.684538

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Copyright © 2021 Cui, Chu, Yin, Chen, Wan, Luo, Dong and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activator of SOCE in the duodenal epithelium. (A,B) serosal CPA(10 μM)-stimulated duodenal I _sc after addition of GdCl₃ (30 μM) in the serosal side (n = 6). (C,D) TPEN-stimulated duodenal I _sc after addition of GdCl3 (30 μM) in the serosal side (n = 6). (E,F) TPEN-stimulated duodenal I _sc after adding HC067047 (30 μM) to the serosal side (n = 6). Ctrl represents the control without drug treatment. Results are presented as mean ± SE. NS, no significant differences, *p < 0.05, **p < 0.01 vs. corresponding control by Student’s unpaired, two-tailed t-test.