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. 2021 Jul 14;12:684538. doi: 10.3389/fphar.2021.684538

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Copyright © 2021 Cui, Chu, Yin, Chen, Wan, Luo, Dong and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanism diagram of secretagogues mediating Ca²⁺ signaling in duodenal epithelial cells via TRPV4-constituted serosal SOCE mechanism. PGE₂ and 5-HT stimulate this mechanism exclusively from serosal side of the duodenum; CCh stimulates it from both sides. 5-HT and CCh trigger the ER Ca²⁺ release to initiate the SOCE likely via IP₃/IP₃R, but PGE₂ triggers it likely via RyR. CaCC, Ca²⁺-activated Cl⁻ channels; CFTR, cystic fibrosis transmembrane conductance regulator; CRAC, Ca²⁺ release-activated Ca²⁺ channel; ER, endoplasmic reticulum; EP, PGE₂ receptor; IP₃ and IP₃R, inositol 1,4,5-triphosphate and its receptor; mAchR, muscarinic acetylcholine receptor; NKA, Na⁺/K⁺ ATPase; RyR, ryanodine receptor; SOC, store-operated channels; TRPV4, transient receptor potential V4; 5-HTR, 5-HT receptor.