FIGURE 3.

The ER Ca²⁺ store and ryanodine receptors in PGE₂ -induced duodenal ion transports. (A,B) PGE₂ (10 μM) -evoked I _sc after serosal (s) application of TPEN (1 mM, n = 6). (C,D) PGE₂-evoked I _sc after dantrolene (Dan, 300 μM, n ≥ 6) was added to the serosal (s). (E) PGE₂-evoked I _sc after LiCl (30 mM, n ≥ 6) was added to the serosal side or both sides (m + s). Ctrl represents the control without drug treatment. Results are presented as mean ± SE. NS, no significant differences, *p < 0.05, ****p < 0.0001 vs. corresponding control by Student’s unpaired, two-tailed t-test or one-way ANOVA followed by Dunnett’s post-test.