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. 2021 Jul 14;12:684538. doi: 10.3389/fphar.2021.684538

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Copyright © 2021 Cui, Chu, Yin, Chen, Wan, Luo, Dong and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PGE₂ induced duodenal ion secretion by serosal TRPV4 channels and NKA. (A,B) on PGE₂-evoked I _sc after HC067047 (30 μM, n = 6) added in serosal (s) side. (C,D) PGE₂ (10 μM) -evoked duodenal I _sc in wild-type (W.T.) and TRPV4 knockout (K.O.) mice (n = 6). (E) PGE₂-evoked I _sc after GdCl₃ (Gd³⁺, 30 μM, n ≥ 6) was added to the serosal (s) side of the TRPV4 KO mice duodenum. (F,G) PGE₂-stimulated I _sc after Ouabain (1 mM, n = 7) was added to the serosal (s) side. Ctrl represents the control without drug treatment. Results are presented as mean ± SE. *p < 0.05, ****p < 0.0001 significantly different from the corresponding control by Student’s unpaired, two-tailed t-test.