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. 2021 Jul 14;12:684538. doi: 10.3389/fphar.2021.684538

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Copyright © 2021 Cui, Chu, Yin, Chen, Wan, Luo, Dong and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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5-HT induced Ca²⁺-dependent duodenal epithelial ion transports. (A) Time courses of 5-HT (10 μM) -evoked I _sc or vehicle (DMSO) when added to serosal (s) or mucosal side. (B) When added to the serosal or mucosal side, vehicle or 5-HT-evoked I _sc peak (n = 6). (C) Time courses of 5-HT-evoked I _sc after extracellular Ca²⁺ omission (0 Ca²⁺) from each side in duodenal mucosal tissues. (D) 5-HT-evoked I _sc peak after Ca²⁺ omission from each side (s or m, n = 6). Ctrl represents as the control in which normal extracellular Ca²⁺ was on both sides. Results are presented mean ± SE. *p < 0.05, ****p < 0.0001 significantly different from the corresponding control by one-way ANOVA followed by Dunnett’s post-test.