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. 2021 Jul 14;12:684538. doi: 10.3389/fphar.2021.684538

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Copyright © 2021 Cui, Chu, Yin, Chen, Wan, Luo, Dong and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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5-HT induced Ca²⁺-dependent intestinal ion secretion by serosal SOCE mechanism in mice duodenum. (A) Time course of 5-HT-evoked I _sc after 2-aminoethoxydiphenyl borate (2-APB, 100 μM, n = 6) added to the serosal or mucosal side. (B) 5-HT-stimulated murine duodenal I _sc peak after 2-APB was added to the serosal or mucosal side. (C) Time course of 5-HT-evoked I _sc after SKF-96365 (SKF, 30 μM, n = 6) added to the serosal or mucosal side. (D) 5-HT-evoked duodenal I _sc peak after SKF-96365 was added to the serosal or mucosal side. (E) Time course of 5-HT-evoked I _sc after GSK-7975A (GSK, 100 μM, n = 6) added to the serosal side. (F) 5-HT-evoked I _sc peak after GSK-7975A was added to the serosal side. (G-H) 5-HT-evoked I _sc after GdCl₃ (Gd³⁺, 30 μM, n = 6) added to the side. Ctrl represents the control without drug treatment. Results are presented as mean ± SE. NS, no significant differences, *p < 0.05, ***p < 0.001 vs. corresponding control by Student's unpaired, two-tailed t-test or one-way ANOVA followed Dunnett’s post-test.