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. 2021 Jul 14;12:684538. doi: 10.3389/fphar.2021.684538

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Copyright © 2021 Cui, Chu, Yin, Chen, Wan, Luo, Dong and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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5-HT induced duodenal ion secretion via serosal TRPV4 channels. (A,B) 5-HT-evoked I _sc after HC067047 (30 μM, n = 6) was added to the serosal (s) side. (C,D) 5-HT (10 μM) -evoked I _sc in wild-type (W.T.) or TRPV4 knockout (K.O.) mice (n = 6). (E) 5-HT-evoked I _sc after GdCl (Gd³⁺, 30 μM, n = 6) was added to the serosal (s) side of the TRPV4 KO mice duodenum. Ctrl represents the control without drug treatment. Results are presented as mean ± SE. NS, no significant differences, *p < 0.05 vs. corresponding control by Student’s unpaired, two-tailed t-test.