Figure 1.

Settings are illustrated for use of the proposed hybrid analyses, where t^R denotes the calendar date when it is no longer proper to continue randomization to placebo, and t^F denotes the calendar date when it would no longer be proper for participants randomized to placebo to remain on placebo and in follow-up.

The solid lines denote calendar times when participants are being randomized to an arm, while the dotted lines denote when follow-up is continued for those randomize before t^R