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. 2021 Jul 28;25:24. doi: 10.1186/s40824-021-00226-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — A SEM images of the prepared ALA-ES gels. B TEM images of ALA-ES in human HS tissue dermis. ALA-ES is indicated using black arrows. C TEM image of OA-UCNP. The nanoparticles show near-spherical shape with an average diameter around 25 nm. D Microscopy images of a section of a sample pig ear skin under 980 nm excitation laser. E Schematic illustration of W/O/W emulsification of HA-PLGA. F Fluorescence microscopic images of histological sections of rat skin at 4 and 12 h after topical application of Rho B-encapsulated HA-PLGA NPs. Scale bar, 100 μm. A, B Reproduced from [63], copyright permission by American Chemical Society 2018. C, D Reproduced from [67], copyright permission by IOP Publishing Ltd. 2020. E, F, G Reproduced from [68], copyright permission by BioMed Central Ltd. 2019