Table 1.
Baseline characteristics of DM and Non-DM cases and controls before and after matching
| Characteristics | Before matching | P | After matching | P | ||
|---|---|---|---|---|---|---|
| Control | T2DM | Control | T2DM | |||
| Number | 171,532 | 10,087 | 18,496 | 9248 | ||
| Age, years | 60.000 [49.000,70.000] | 61.000 [53.000,69.000] | < 0.001 | 60.0 [52.0,68.0] | 60.0 [52.0,68.0] | 0.958 |
| Male, n (%) | 93,900 (54%) | 5325 (52%) | < 0.001 | 9670 (52%) | 4832 (52%) | 0.959 |
| Current smoking status, n (%) | 113,057 (65%) | 7917 (78%) | < 0.001 | 14,514 (78%) | 7262 (78%) | 0.918 |
| Current alcohol consumption status, n (%) | 9719 (5%) | 645 (6%) | 0.002 | 1125 (6%) | 594 (6%) | 0.267 |
| CHD, n (%) | 16,814 (9%) | 526 (5%) | < 0.001 | 904 (4%) | 456 (4%) | 0.875 |
| Hypertension, n (%) | 55,313 (32%) | 3916 (38%) | < 0.001 | 6847 (37%) | 3423 (37%) | 0.993 |
| BMI | 22.769 [21.214,24.347] | 23.723 [22.276,25.073] | < 0.001 | 23.73 [22.27,25.07] | 23.74 [22.28,25.10] | 0.425 |
| Lp(a), mg/dL | 17.270 [9.170,29.720] | 16.750 [8.920,28.580] | 0.001 | 16.88 [8.92,29.07] | 16.42 [8.8,28.0] | 0.015 |
| SBP, mmHg | 126.000 [119.660,136.000] | 130.000 [120.000,140.000] | < 0.001 | 127.83 [120.0,138.0] | 129.91 [120.0,139.25] | < 0.001 |
| DBP, mmHg | 76.000 [70.000,80.000] | 77.310 [72.680,81.000] | < 0.001 | 76.54 [70.0,80.92] | 77.3 [72.83,81.0] | < 0.001 |
| TC, mmol/L | 4.290 [3.620,5.000] | 4.520 [3.840,5.250] | < 0.001 | 4.46 [3.77,5.16] | 4.53 [3.86,5.25] | < 0.001 |
| TG, mmol/L | 1.190 [0.870,1.710] | 1.420 [1.010,2.070] | < 0.001 | 1.34 [0.96,1.93] | 1.41 [1.0,2.07] | < 0.001 |
| HDL-c, mmol/L | 1.050 [0.860,1.270] | 1.010 [0.840,1.210] | < 0.001 | 1.04 [0.86,1.25] | 1.01 [0.85,1.22] | < 0.001 |
| LDL-c, mmol/L | 2.520 [1.990,3.110] | 2.690 [2.120,3.300] | < 0.001 | 2.64 [2.09,3.22] | 2.7 [2.14,3.3] | < 0.001 |
| ApoA, mmol/L | 1.050 [0.880,1.230] | 1.050 [0.900,1.220] | 0.081 | 1.06 [0.9,1.24] | 1.05 [0.9,1.22] | 0.096 |
| ApoB, mmol/L | 0.770 [0.640,0.930] | 0.830 [0.690,1.000] | < 0.001 | 0.81 [0.67,0.96] | 0.83 [0.69,1.0] | < 0.001 |
| eGFR, mL/(min·1.73 m2) | 97.483 [81.653,113.860] | 101.990 [83.391,120.894] | < 0.001 | 97.81 [85.03,112.20] | 104.85 [88.69,122.85] | < 0.001 |
| Fasting Glucose, mmol/L | 4.990 [4.510,5.740] | 7.820 [5.940,11.030] | < 0.001 | 5.11 [4.62,5.87] | 7.88 [5.99,11.03] | < 0.001 |
| HbA1c, % | 5.713 [5.500,6.031] | 7.700 [6.500,9.800] | < 0.001 | 5.79 [5.54,6.10] | 7.7 [6.5,9.86] | < 0.001 |
| Creatinine, mmol/L | 68.879 [57.200,82.610] | 65.800 [54.080,80.200] | < 0.001 | 67.4 [56.9,79.0] | 63.96 [52.9,75.6] | < 0.001 |
| HCY, μmol/L | 13.447 [11.133,16.380] | 11.842 [9.910,14.452] | < 0.001 | 13.090 [11.10,15.60] | 11.57 [9.76,13.82] | < 0.001 |
| hsCRP, mg/dL | 4.362 [2.000,15.492] | 4.186 [2.365,10.414] | 0.628 | 3.85 [2.04,11.53] | 3.917 [2.3,9.03] | 0.317 |
Continuous variables presented as median (25, 75%)
ApoA, apolipoprotein A; ApoB, apolipoprotein B; BMI, body mass index; CHD, coronary heart disease; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; HbA1c, glycosylated hemoglobin; hsCRP, high-sensitivity C-reactive protein; HCY, homocysteine; HDL-c, high density lipoprotein cholesterol; LDL-c, low density lipoprotein cholesterol; Lp(a), lipoprotein (a); SBP, systolic blood pressure; TC, total cholesterol; TG, triglyceride