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. 2021 Jul 28;23:202. doi: 10.1186/s13075-021-02580-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Differential DNA methylation in hyperuricemic versus normouricemic people. Principal component analysis of whole blood DNA methylation data, obtained using Illumina InfiniumMethylationEPIC BeadChips in whole blood of 26 people with hyperuricemia compared to 50 normouricemic individuals (A). Differentially methylated regions (DMRs) at the HLA-G locus (B) and average DNA methylation levels (beta values) for all CpG probes found within HLA-G (ticks on the x-axis represent individual probes and DNA chromosome position is indicated) (C). Transcription factors are known to bind at the highlighted DMR1 and DMR3 regions according to the transcription factor ChIP-seq clusters from ENCODE with factorbook motifs (D)