Table 1.

The schedule for enrollment, the interventions, and the assessments

	Study period
	Enrollment	Allocation	Post-allocation
Timepoint	-t2	-t1	T0	T6	T12
Enrollment:
Eligibility screen	X
Informed consent	X
Allocation		X
Washout period		X
Intervention:
Administration of GSM supplement and placebo			X	X	X
Assessments:
Blood and urine sample collection			X	X	X
Pain assessment; VAS and KOOS			X		X
Body composition, DXA scan			X		X
Food intake; 3-day food record				X
Compliance				X	X