Table 6.
Cornell Scale for Depression in Dementia predicted by week, condition, dementia severity and baseline total using multilevel regression
| Predictors | Total | Mood-related signs | Behavioral disturbance | Cyclic functions | ||||
|---|---|---|---|---|---|---|---|---|
| Estimates (CI) | Std. betas (SD) | Estimates (CI) | Std. betas (SD) | Estimates (CI) | Std. betas (SD) | Estimates (CI) | Std. betas (SD) | |
| Week (8) | 1.6 (− 0.3–3.5) | 0.3 (1.6) | 0.6 (− 0.1–1.2) | 0.3 (1.8) | 0.5 (− 0.2–1.1) | 0.3 (1.3) | 0.4 (− 0.3–1.0) | 0.2 (1.1) |
| Week (16) | -0.8 (−2.8–1.3) | -0.1 (− 0.7) | 0.3 (− 0.3–1.0) | 0.2 (1.0) | − 0.6 (− 1.3–0.1) | − 0.4 (− 1.7) | − 0.6 (− 1.3–0.1) | − 0.3 (− 1.6) |
| Week (24) | − 1.2 (−3.2–0.8) | − 0.2 (− 1.2) | 0.1 (− 0.5–0.8) | 0.1 (0.5) | −0.4 (− 1.1–0.3) | −0.2 (− 1.1) | −0.6 (− 1.3–0.1) | −0.3 (− 1.7) |
| Condition [Intervention] | 2.1 (− 0.1–4.2) | 0.4 (1.9) | 0.6 (− 0.1–1.3) | 0.3 (1.6) | 0.4 (− 0.3–1.1) | 0.2 (1.1) | 0.5 (−0.1–1.2) | 0.3 (1.6) |
| Interactions (indicating treatment effect) | ||||||||
| Week (8) * [Intervention] | −2.7 (−5.4–0.0) | −0.5 (− 1.9) | − 1.0 *(− 1.9 – − 0.1) | − 0.5 (− 2.3) | −0.4 (− 1.4–0.5) | −0.2 (− 0.9) | −0.6 (− 1.5–0.3) | −0.3 (− 1.3) |
| Week (16) * [Intervention] | − 3.2 *(−6.0 – − 0.3) | − 0.6 (− 2.2) | −1.8 ***(− 2.7 – − 0.8) | −0.9 (− 3.8) | −0.0 (− 1.0–0.9) | −0.0 (− 0.1) | −0.1 (− 1.1–0.8) | −0.1 (− 0.3) |
| Week (24) * [Intervention] | −1.0 (− 3.8–1.8) | −0.2 (− 0.7) | −0.8 (− 1.6–0.1) | −0.4 (− 1.7) | 0.4 (− 0.5–1.4) | 0.3 (0.9) | −0.5 (− 1.5–0.4) | −0.3 (− 1.1) |
| Covariates | ||||||||
| FAST | 0.2 (−0.9–1.2) | 0.0 (0.3) | −0.3 (− 0.6–0.1) | −0.1 (− 1.5) | 0.1 (− 0.3–0.4) | 0.0 (0.3) | 0.2 (− 0.1–0.6) | 0.1 (1.4) |
| Baseline DV | 0.6 ***(0.4–0.7) | 0.6 (8.6) | 0.6 ***(0.5–0.8) | 0.7 (8.8) | 0.5 ***(0.4–0.6) | 0.5 (7.4) | 0.5 ***(0.4–0.6) | 0.6 (9.6) |
| Model information | ||||||||
| ICC (id) | 0.25 | 0.32 | 0.18 | 0.11 | ||||
| Marginal R2 / Conditional R2 | 0.423 / 0.567 | 0.436 / 0.614 | 0.334 / 0.454 | 0.415 / 0.480 | ||||
* p < 0.05, ** p < 0.01, *** p < 0.001. In italics: significant after Benjamini-Hochberg correction for false discovery rate with all eight models. Std. betas standardized regression coefficients, SD standard deviation, CI 95% confidence interval, SD standard deviation, FAST Functional Assessment Staging Test, DV dependent variable, ICC intraclass correlation coefficient