Table 1.
Clinical features of 46 Chinese CF patients at the time of diagnosis
| Variables | N = 46 |
|---|---|
| Sex –no (%) | 46 |
| Female - no (%) | 20 (43.48%) |
| Male - no (%) | 26 (56.52%) |
| Age of onset of symptoms -year | 4.05 ± 3.77 (0–12, median2.50) |
| Age at diagnosis -year | 8.05 ± 4.26 (0.59–15.88, median 8.74) |
| Diagnostic delay -year | 4.01 ± 3.72 (0.14–12.44, median 3.05) |
| Pulmonary symptoms | |
| Cough -no/total no (%) | 46/46 (100.00) |
| Wheezing -no/total no (%) | 12/46 (26.09) |
| Extra pulmonary symptoms | 3/46 (6.52) |
| Respiratory infection times | 4.49 ± 2.13 |
| Pancreatic malfunction –no/total no (%) | 18/46 (39.13) |
| ABPA -no/total no (%) | 14/46 (30.43) |
| Asthma -no/total no (%) | 10/46 (21.74) |
| Lung function -no/total no (%) | 31/46 (67.39) |
| FEV1 | 75.44% ± 22.40% (25.1–118.2%,74.5%) |
| FVC | 83.59% ± 16.99% (33.1–113.9%,86.1%) |
| FEF75 | 39.45% ± 26.68%(6.6–112.9%,33.3%) |
| Bacterial colonies n (%) -no/total no (%) | 46/46 (100.00) |
| PA -no/total no (%) | 33/46 (71.74) |
| SA -no/total no (%) | 9/46 (19.57) |
| CT scan | 46/46 (100.00) |
| Bronchiectasis -no/total no (%) | 42/46 (91.30) |
| Only Inflammation -no/total no (%) | 4/46 (8.70) |
| Mucus plugging -no/total no (%) | 14/46 (30.43) |
| Pleural thickening -no/total no (%) | 14/46 (30.43) |
Plus–minus values are means ± SD.
ABPA Allergic bronchopulmonary aspergillosis, PA Pseudomonas aeruginosa, SA Staphylococcus aureus. Normal/mild disease: FEV1 > 70% predicted, Moderate obstruction: FEV1 ranges from 40 to 69% predicted, Severe disease: FEV1 less than 40% [10].