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Coincidence of enzymatic and spontaneous PTMs at Ser and Asp residues of Aβ in the neurodegenerative amyloid aggregates.
| Peptide | Disease | Residue | PTMs | ||
|---|---|---|---|---|---|
| Rcm. | Ism. | Ph. | |||
| Spontaneous | Enzymic | ||||
| Ser-8 | [24, 35] | [3, 40, 41, 42] | |||
| A-β (40–42) | AD | Ser-26 | [13, 35, 36] | [43. 44] | |
| Asp-23 | [35, 37, 38] | [40] | |||
| A-β (20–34) | Asp-23 | [39] | |||
Post-translational modification (PTMs): Spontaneous (Sp) and Enzymic (Enz), Racemization (Rcm). Isomerization (Ism). Phosphorylation (Ph).
