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. 2021 Jul 14;12:682767. doi: 10.3389/fphar.2021.682767

FIGURE 1.

FIGURE 1

Perampanel suppressed seizure activity in Scn1a E1099X/+ mice with spontaneous recurrent seizures. (A) Schematic illustration of the experimental protocols (each illustration is an original drawing made by the authors). (B) Representative EEG trace (2.2–7.0 Hz) of one spontaneous seizure event in vehicle and PER treatment groups (n = 3 per group). (C) Quantitative results of the ictal discharge event during EEG recording, including seizure duration and frequency in vehicle and PER treatment groups (n = 3 per group). N.D., not determined. (D) Interictal spikes (indicated by asterisks) are illustrated. Interictal spikes in the PER treatment group (n = 3 per group) were significantly decreased during a period of seven-day administration in comparison with the vehicle group (n = 3 per group). (E) Quantitative results of interictal spikes from (D). *p < 0.05, Student’s paired t-test.