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. 2021 Jul 14;12:682767. doi: 10.3389/fphar.2021.682767

FIGURE 4.

FIGURE 4

Efficacy of PER in combination therapy for hyperthermia-induced seizure in Scn1a E1099X/+ mice. (A) EEG representative data show the results of single drug STP (stiripentol, 300 mg/kg), VPA (valproic acid, 120 mg/kg), and PHT (phenytoin, 100 mg/kg) treatment. (B) EEG images recorded during combination therapy of PER (1 mg/kg) + STP (150 mg/kg), PER (1 mg/kg) + VPA (60 mg/kg), and STP + VPA. The temperature change, seizure duration, and Racine score were recorded for a single drug or combination therapy (n = 3 per group). **p < 0.01, ***p < 0.001. (C) One-way ANOVA followed by Tukey’s multiple comparisons post hoc analysis in temperature and seizure duration and (D) Student’s unpaired t-test. N.D., not determined.