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Diagrammatic representation of structurally different ligands in the ABCG2 binding cavity and a depiction of the F439 interaction. A, Hoeschst 33342. B, Pheophorbide a. C, Mitoxantrone. D, Topotecan. E, Sunitinib. F439 (yellow) provides an anchoring point for ABCG2 ligands (A-E). F, “A” and “B” indicate F439 has been donated from separate ABCG2 monomers. The molecule that will interdigitate between the two F439 is the ABCG2 substrate and chemotherapeutic agent, mitoxantrone
