Table 3.
Withdrawn drugs due to severe cardiovascular effects.
| PubChem (CID) | Category and drug | APOD Score (Benefits-Risks) | N-APOD (WRGLSBADMET) | |
|---|---|---|---|---|
| Strong safety profile | ||||
| 1 | 16574 | Azaribine | 7–2 | 79209069450 |
| 2 | 135413539 | Tegaserod maleate | 7–2 | 87909059650 |
| Moderate safety profile | ||||
| 3 | 71329 | Dofetilide | 5–4 | 88438046532 |
| 4 | 72474 | Grepafloxacin | 6–3 | 77404057452 |
| 5 | 39371 | Levomethadyl acetate HCl | 5–4 | 73201046354 |
| 6 | 60662 | Mibefradil dihydrochloride | 5–3 | 96604047542 |
| 7 | 4086 | Orciprenaline | 6–3 | 44814066463 |
| 8 | 60464 | Sparfloxacin | 6–2 | 79606058551 |
| Weak safety profile | ||||
| 9 | 2247 | Astemizole | 0–8 | 95292000608 |
| 10 | 2467 | Buflomedil | 3–5 | 65043034345 |
| 11 | 2318 | Benfluorex | 0–8 | 76292010618 |
| 12 | 10007 | Chlorphentermine | 3–5 | 31251043256 |
| 13 | 6917698 | Cisapride monohydrate | 2–6 | 97465023615 |
| 14 | 26602 | Cloforex | 2–6 | 52272022437 |
| 15 | 26937 | Clobutinol | 2–6 | 52261032337 |
| 16 | 66265 | Dexfenfluramine | 2–6 | 44260032447 |
| 17 | 5702697 | Dithiazanine iodide | 2–6 | 94064023415 |
| 18 | 48040 | Encainide HCl | 3–5 | 73432034445 |
| 19 | 3337 | Fenfluramine | 2–6 | 44260032447 |
| 20 | 47811 | Pergolide mesylate | 1–7 | 62282021427 |
| 21 | 9801 | Prenylamine | 0–8 | 61290010419 |
| 22 | 10100 | Propoxyphene | 1–7 | 63081011428 |
| 23 | 5090 | Rofecoxib | 4–4 | 64044044344 |
| 24 | 77999 | Rosiglitazone | 3–5 | 76266034524 |
| 25 | 60149 | Sertindole | 1–7 | 83282011517 |
| 26 | 5210 | Sibutramine | 0–8 | 51090010329 |
| 27 | 5405 | Terfenadine | 0–8 | 93492000608 |
| 28 | 23480 | Terodiline | 0–8 | 51290010429 |
| 29 | 5452 | Thioridazine | 1–7 | 74093011517 |
| 30 | 119607 | Valdecoxib | 4–5 | 65256044434 |