Table 4.
Cytochrome P450 CYP3A4 inhibitors.
| PubChem (CID) | Category and drug | APOD Score (Benefits-Risks) | N-APOD (WRGLSBADMET) | |
|---|---|---|---|---|
| Strong safety profile | ||||
| 1 | 1349907 | Methimazole | 7–2 | 21203077183 |
| Weak safety profile | ||||
| 2 | 71616 | Voriconazole | 4–4 | 68235045443 |
| 3 | 3002190 | Telithromycin | 2–6 | 99289023704 |
| 4 | 456201 | Ketoconazole | 1–7 | 96084012506 |
| 5 | 4449 | Nefazodone | 1–8 | 95083011507 |
| 6 | 3793 | Itraconazole | 1–7 | 99096012606 |
| 7 | 84029 | Clarithromycin | 4–5 | 99869035813 |
| 8 | 441243 | Saquinavir | 2–6 | 97989023804 |
| 9 | 213039 | Darunavir | 4–4 | 99659035722 |
| 10 | 468595 | Posaconazole | 1–7 | 99297012705 |
| 11 | 92727 | Lopinavir | 1–7 | 95898012705 |
| 12 | 3010818 | Telaprevir | 2–6 | 98889023804 |
| 13 | 11625818 | Idelalisib | 2–6 | 87476023615 |
| 14 | 25151504 | Cobicistat | 2–6 | 99699013804 |
| 15 | 5311454 | Stiripentol | 2–6 | 43272032437 |
| 16 | 969516 | Curcumin | 3–5 | 76466034524 |
| 17 | 392622 | Ritonavir | 2–6 | 99899013804 |
| 18 | 151171 | Conivaptan | 1–7 | 93495011606 |
| 19 | 202225 | Troleandomycin | 2–6 | 99089023604 |
| 20 | 64139 | Efavirenz | 1–7 | 65282021527 |
| 21 | 148192 | Atazanavir | 2–6 | 99999013904 |
| 22 | 54682461 | Tipranavir | 1–7 | 99497012705 |
| 23 | 5284596 | Naloxone | 4–4 | 65444044444 |
| 24 | 644241 | Nilotinib | 1–7 | 99496012706 |
| 25 | 5625 | Delavirdine | 4–5 | 97647035623 |
| 26 | 3955 | Loperamide | 0–8 | 93292000508 |
| 27 | 44631912 | Ribociclib | 4–4 | 87446035533 |
| 28 | 11285588 | Danoprevir | 4–5 | 99669035713 |
| 29 | 5277135 | Elvitegravir | 1–7 | 87495011706 |
| 30 | 9829523 | Midostaurin | 1–7 | 94295011606 |
| 31 | 5405 | Terfenadine | 0–8 | 93492000608 |
| 32 | 8223 | Ergotamine | 4–5 | 96647035623 |
| 33 | 3198 | Econazole | 0–8 | 72091010418 |
| 34 | 8987 | Ditiocarb | 4–4 | 22232054265 |
| 35 | 5362440 | Indinavir | 4–5 | 97857035723 |
| 36 | 64143 | Nelfinavir | 1–7 | 96898012805 |
| 37 | 10324367 | Boceprevir | 4–5 | 95869035713 |
| 38 | 28417 | Danazol | 2–6 | 63273022426 |
| 39 | 39186 | Diltiazem | 2–6 | 86065023525 |
| 40 | 148195 | Lonafarnib | 1–7 | 93295011506 |