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. Author manuscript; available in PMC: 2021 Aug 11.
Published in final edited form as: Immunity. 2021 Apr 9;54(5):931–946.e11. doi: 10.1016/j.immuni.2021.03.020

Figure 7. Genetic perturbation of Aire exacerbates autoimmunity in CNS0-deficient animals.

Figure 7.

A. Representative images of hematoxylin and eosin stained slides. Arrows indicate aggregates of inflammatory cells and arrowheads circumscribe the inflammatory regions. Scale bars indicate 100 μm (lung, liver), 50 μm (salivary gland, small intestine, and adipose tissue), or 20 μm (eye).

B. Histopathological scoring. Shading indicates mean score for each group (0–4) and p values denote two-way ANOVA with Sidak test to correct for multiple comparisons.

C, D. Frequencies of CD44+CD62L− cells among CD4+Foxp3-GFP− T cells (C) and CD44+CD62L− cells among CD8+ T cells (D).

Unpaired t-tests with correction for multiple comparisons using the Holm-Sidak method. p >0.05 ns or blank (B), <0.05 *, <0.01 **, <0.001 ***, <0.0001 ****.