Table 1.
Mutations detected in the 1816 BRAF/NRAS wild-type patients
| Mutations | Codons | Amino acid alteration | Number of patients |
|---|---|---|---|
| Wild type | 927 | ||
| KRAS exon 2 mutation | Codon 12 | p.G12D | 174 |
| p.G12V | 121 | ||
| p.G12S | 36 | ||
| p.G12C | 26 | ||
| p.G12A | 15 | ||
| p.G12R | 8 | ||
| Other amino acid alteration | 7 | ||
| Unknown amino acid alteration | 153 | ||
| Codon 13 | P.G13D | 184 | |
| p.G13R | 3 | ||
| p.G13C | 1 | ||
| p.G13V | 1 | ||
| Unknown codon | 51 | ||
| KRAS exon 3 mutation | Codon 61 | p.Q61H | 8 |
| p.Q61L | 7 | ||
| p.Q61R | 5 | ||
| p.Q61K | 2 | ||
| Codon 59 | p.A59T | 2 | |
| Unknown codon | 10 | ||
| KRAS exon 4 mutation | Codon 146 | p.A146T | 44 |
| p.A146V | 4 | ||
| p.A146N | 1 | ||
| Codon 117 | p.K117D | 5 | |
| p.K117N | 3 | ||
| p.K117R | 1 | ||
| Codon 131 | p.Q131fs | 1 | |
| Unknown codon | 16 |