Table 3.

Multivariate analysis of the clinicopathologic features

Variables	Multivariate analysis
	KRAS		KRAS exon 2		KRAS exon 3		KRAS exon 4
	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)
Sex (Male)	0.002	0.728 (0.598-0.887)	0.006	0.752 (0.614-0.922)	0.035	0.473 (0.236-0.947)
Age	0.001	1.016 (1.008-1.025)	0.002	1.014 (1.005-1.022)			0.002	1.035 (1.013-1.058)
Tumor site
Rectum	Ref	1	Ref	1			Ref	1
Left	0.001	0.535 (0.424-0.675)	0.001	0.545 (0.428-0.694)			0.001	0.328 (0.165-0.651)
Right	0.008	1.388 (1.088-1.773)	0.002	1.475 (1.151-1.892)			0.750	0.909 (0.505-1.637)
CEA level (>5 μg/L)	0.001	1.390 (1.140-1.695)	0.002	1.376 (1.121-1.689)
TNM stage
I	Ref	1	Ref	1
II	0.160	1.310 (0.899-1.908)	0.068	1.448 (0.973-2.155)
III	0.244	1.248 (0.860-1.810)	0.066	1.443 (0.975-2.134)
IV	0.008	1.678 (1.143-2.464)	0.002	1.868 (1.246-2.801)
Histological
Ulcer type	Ref	1	Ref	1			Ref	1
Tumor type	0.001	1.632 (1.307-2.037)	0.001	1.699 (1.352-2.136)			0.006	2.009 (1.219-3.311)
Invasive type	0.270	0.751 (0.452-1.248)	0.407	0.803 (0.479-1.348)			0.263	0.314 (0.041-2.385)
Pathology (Mucinous)	0.038	1.310 (1.015-1.692)					0.001	3.800 (1.974-7.313)
Extranodal tumor deposit	0.038	1.310 (1.015-1.692)	0.034	1.329 (1.022-1.729)	0.029	2.249 (1.087-4.653)