Table 1.

Known circRNAs-RBPs interactions in several common types of tumors

Cancer	CircRNA	Dysregulation	Type of tissue/cell lines	RBPs	CircRNAs-RBPs interaction	Participation	Ref.
Breast cancer	circFOXO3	down	BC tissues and cells	MDM2,p53	protein scaffold	apoptosis	2017 42
	FECR1	up	BC tissues	TET1	protein recruiter	invasion, metastasis	2017 46
	circ-Ccnb1	down	BC cell lines	H2AX,p53; H2AX,Bcla1	protein scaffold	proliferation, apoptosis	2017 33
	circDNMT1	up	BC cell lines	p53,AUF1	protein translocation	autophagy mediated cell proliferation, survival, and tumor growth	2018 32
	circMTO1	down	monastrol-resistant cell lines	TRAF4	protein decoy	monastrol resistance	2018 49
	circSKA3	up	BC tissues and cells	Interinβ1,Tks5	protein scaffold	migration, invasion	2020 43
Liver cancer	circRHOT1	up	HCC tissues	TIP60	protein recruiter	proliferation, migration, invasion	2019 54
	circ-ADD3	down	HCC tissues	EZH2,CDK1	protein scaffold	migration, invasion, metastasis	2019 38
	circZKSCAN1	down	HCC tissues	FMRP	protein decoy	tumor quiescence	2019 57
	circ-cIARS	up	SF-treated HCC cells	ALKBH5	protein decoy	autophagy	2020 60
	circ-LRIG3	up	HCC tissues, cells and plasma	EZH2,STAT3	protein scaffold	tumorigenicity, metastasis	2020 64
	circBACH1	up	HCC tissues	HuR	protein translocation	proliferation	2020 63
Gastric cancer	circAGO2	up	GC tissues and cells	HuR	protein translocation	growth, invasion, metastasis	2019 66
	circFAT1(e2)	down	GC tissues and cells	YBX1	protein decoy	proliferation, migration, invasion	2019 69
	circMRPS35	down	GC tissues	KAT7	protein recruiter	growth, invasion, metastasis	2020 72
	circ-HuR	down	GC tissues and cells	CNBP	protein decoy	growth, invasion, metastasis	2020 75
Lung cancer	circNOL10	down	LC tissues	SCML1	protein defender	apoptosis, proliferation, cell cycle progression	2019 79
	circ-SOX4	up	CD133+ NSCLC cells	β-catenin, c-MYC	protein translocation, protein defender	TICs proliferation, self-renewal, migration, invasion	2020 81
	circNOTCH1	up	NSCLC cell lines	METTL14	protein decoy	NSCLC cell growth	2020 84
Glioblastoma	circSMARCA5	down	GBM tissues	SRSF1	protein decoy	migration, angiogenesis	2018 87, 2019 88
	CDR1as	down	GBM tissues	MDM2,p53	protein defender	colony formation, proliferation, cell cycle progression, apoptosis	2020 90