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. 2021 Jul 14;8:683506. doi: 10.3389/fmed.2021.683506

Figure 2.

Figure 2

Immunohistochemistry analysis of hepatic BRD4 protein expression in liver fibrosis/cirrhosis. (A) Immunohistochemistry analysis was performed to examine hepatic BRD4 protein expression patterns in normal liver tissues and liver fibrosis of various etiologies. The control sections were incubated with IgG. Representative images of normal hepatic tissues, HBV, HCV, AIH, NASH, cholelithiasis, and overlap syndrome. Scale bar: 50 μm. The expression level of BRD4 was analysis by Image J software. Data were expressed as mean ± SEM or median M (P25, P75). Differences between groups were evaluated using two independent samples t-test or Mann-Whitney U rank-sum test. (B) Immunohistochemistry analysis was performed to examine hepatic BRD4 protein expression patterns in normal liver tissues and liver cirrhosis of various etiologies. The control sections were incubated with IgG. Representative images of normal hepatic tissues, HBV, HCV, AIH, PBC, cholelithiasis, and overlap syndrome. Scale bar: 50 μm. The expression level of BRD4 was analysis by Image J software. Data were expressed as mean ± SEM or median M (P25, P75). Differences between groups were evaluated using two independent samples t-test or Mann-Whitney U rank-sum test. *P < 0.05; **P < 0.01; ***P < 0.0001; ****P < 0.00001 vs. normal control. BRD4, bromodomain-containing protein 4; HBV, hepatitis B virus; HCV, hepatitis C virus; AIH, autoimmune hepatitis; NASH, non-alcoholic steatohepatitis; PBC, primary sclerosing cholangitis.